Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.

نویسندگان

  • C D Kirkwood
  • R F Bishop
  • B S Coulson
چکیده

Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes.

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عنوان ژورنال:
  • Journal of virology

دوره 72 11  شماره 

صفحات  -

تاریخ انتشار 1998